From Marseilles, 65km south, take the A-7 autoroute north (direction Lyon); the exit toward L'Isle sur la Sorgue is well marked.
Avignon is 25 km west of L'Isle sur la Sorgue. Take the N-7 south toward Cavaillon and then the D938 toward LIsle-sur-la-Sorgue.
There is a bus service from the TGV station in Avignon. Check the schedule as it changes frequently. The drop off point is 100m from the apartment.
Note that there is a map on the "Home Page"